Simmons found popularity between 2005-2009 with her family's MTV reality show Run's House. She and her sister, Angela Simmons, are designers for the shoe brand Pastry. Simmons appeared briefly on the soap opera television show Guiding Light and held a role in the film Speed Dating. In 2008 she secretly entered the Miss California USA pageant. She is in Boogie Town and the ensemble film Dysfunctional Friends. She also starred in the 2014 web series, Mixed. Simmons became the host and judge of Project Runway: Threads in 2014.