Khan's parents are former Bollywood actor Sanjay Khan and interior designer Zarine Khan. His father is of mixed Pashtun and Iranian descent while his mother comes from a Parsi family. Zayed, who was raised as a Muslim, is the youngest of four children and the only son of his parents. His elder sisters are Simone Khan (married to Ajay Arora), Suzanne Roshan (ex-wife of actor Hrithik Roshan), and Farah Khan Ali (married to DJ Aqeel). Khan is the nephew of late actor Feroz Khan and director Akbar Khan (brothers of Sanjay Khan) and first cousin of Bollywood actor, Fardeen Khan.