Born in New York City and raised in London, she was the niece of Pakistani actresses Sangeeta and Kaveeta. Khan always aspired to pursue a career in acting and moved to Mumbai for a film career. She made her film debut in the 2007 Ram Gopal Verma film Nishabd for which she was nominated for Filmfare Award for Best Female Debut. She was later noted for portraying a modern, independent woman in Ghajini which was the highest-grossing Bollywood film of 2008. Her performance in the latter earned her significant acclaim. Her final film appearance was in Sajid Khan's romantic comedy Housefull, which was the fifth highest-grossing Bollywood film of 2010. Khan had catapulted herself into the Bollywood 100 Crore Club with Ghajini and Housefull.