Resistance 2 is a single-player campaign, with the player controlling protagonist Nathan Hale. The game includes many of the weapons from Resistance: Fall of Man, as well as new weapons such as the "Marksman" and a mini gun called the "HVAP (High Velocity Armor Piercing) Wraith". The weapons are a mix of 1950s human technology and more advanced alien technology. Unlike the first game, where there was no limit on the number of weapons carried, Resistance 2 limited the player to only two weapons at any given time, as well as a more limited number of grenades. Resistance 2 also does not use a health bar in the single player campaign as it did in the first, but instead it uses an automatic regenerative health system, whereby players must keep out of the line of fire in order to recover health.