Lisa Ann was born and raised in Easton, Pennsylvania. She entered the adult film industry in 1994. Her first scene was in Cinesex 2.  During the first two years of her adult film career, she was under contract with Metro/Cal Vista and shot only once a month with famous porn artist John O'Rourke. She quit porn in 1997 due to an AIDS scare in the industry and spent the following seven years stripping. She also owned a day spa for four years during her hiatus from porn. She decided to resume performing in February 2006 after being asked to do a boy/girl photo shoot for Suze Randall. The first scene she shot after returning to the industry was with Christian XXX in Bra Bustin' and Deep Thrustin'. In addition to her work as a performer, she also has credits as a director, producer, and for makeup.