Louis Creed, a doctor from Chicago, is appointed director of the University of Maine's campus health service. He moves to a large house near the small town of Ludlow with his wife Rachel, their two young children, Ellie and Gage, and Ellie's cat, Church. From the moment they arrive, the family runs into trouble: Ellie hurts her knee and Gage is stung by a bee. Their new neighbor, an elderly man named Jud Crandall, comes to help. He warns Louis and Rachel about the highway that runs past their house, which is frequented by speeding trucks.