Bryant began attending Clemson University in 2011. Coming into Clemson, he had to compete with future NFL players, Sammy Watkins, DeAndre Hopkins, and Jaron Brown. His first reception was for 54 yards against Troy on September 3. The next week, he had his first career touchdown, a 42-yard reception while playing Wofford. His first career start was against #10 Virginia Tech on October 1, 2011. He also played in his first bowl game, against #22 West Virginia in the Orange Bowl. In that game, he caught 2 passes for 20 yards. He completed his first season with 2 starts in 14 games. He finished 2011 with 9 receptions, 220 receiving yards, and 2 touchdowns.