Centineo was born in Miami, Florida, to Kellee Janel and Gregory Vincent Centineo, an executive producer for film. Centineo stated he is half Italian, Dutch, and a little Native American. He grew up in Boynton Beach, Florida, and has an older sister, Taylor. He attended BAK Middle School of the Arts, and then Boca Raton Community High School for ninth and tenth grade, where he played soccer. In 2012, he moved to Los Angeles.