Urie was born in St. George, Utah, and his family moved to Las Vegas, Nevada, when he was two years old. He is the fifth and youngest child born to Grace and Boyd Urie. He is of about one quarter Polynesian descent from Hawaii, through his mother's side. He was raised in an LDS family, but left the faith around 17 due to displeasure with the church and not believing in its ideology. Urie attended Palo Verde High School in Las Vegas, where he met future Panic! bassist Brent Wilson in his guitar class. Wilson asked Urie to try out for a band he was in, since they needed a replacement guitarist.