Matthews was one of only four receivers to make the final 53-man roster in 2013. This was crucial after seeing Dustin Keller go down in a preseason game against the Houston Texans. Matthews was a second-year player adding to the likes of Mike Wallace, Brian Hartline, and Brandon Gibson. Matthews had his first two-touchdown game in another losing effort against the Tampa Bay Buccaneers on November 11, 2013. He finished the Monday Night Football game with 120 yards on 11 receptions. After Miami's Brandon Gibson went down in Week 11, Matthews has received a large increase in targets and a number of starts. Matthews proved to be a reliable target, specifically in the Miami win against the New England Patriots on December 15, 2013. Matthews caught a 24-yard reception to keep the drive alive in the 24-20 upset. The 2013 season came to an end with Matthews contributing 41 receptions for 448 yards and 2 touchdowns.